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Article

Genetic engineering of taxol biosynthetic genes in <i>Saccharomyces cerevisiae</i>

13 Sept 2005

Abstract excerpt

Baccatin III, an intermediate of Taxol biosynthesis and a useful precursor for semisynthesis of the anti-cancer drug, is produced in yew (Taxus) species by a sequence of 15 enzymatic steps from primary metabolism. Ten genes encoding enzymes of this extended pathway have been described, thereby permitting a preliminary attempt to reconstruct early steps of taxane diterpenoid (taxoid) metabolism in Saccharomyces...

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PMID: 16161138
DOI: 10.1002/bit.20694

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