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Article

Androgen receptor mutations and polymorphisms in African American prostate cancer.

International journal of biological sciences - 1 Jan 2014

Koochekpour Shahriar, Buckles Erick, Shourideh Mojgan, Hu SiYi, Chandra Dhyan, Zabaleta Jovanny, Attwood Kristopher

Abstract excerpt

The Androgen receptor (AR) plays a central role in the normal development of the prostate gland, in prostate carcinogenesis, and in the progression of prostate cancer (PCa) to advanced metastatic disease. African American (AA) men with PCa present with higher tumor volume, more advanced tumor stage, and higher Gleason score. This could be in part related to the AR expression or activity in the prostate tissue of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24948877
DOI: 10.7150/ijbs.8974
PMCID: PMC4062957

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