Article

c-Myc inhibition is critical for HSC expansion and Rad51 expression

2018-09-04

Abstract excerpt

c-Myc plays a major role in the maintenance of glycolytic metabolism and hematopoietic stem cell (HSC) quiescence. Targeting modulators of HSC quiescence and metabolism could lead to HSC cell cycle entry with concomitant expansion. Here we show that c-Myc inhibitor 10074-G5 treatment leads to 2-fold increase in murine LSKCD34low HSC compartment post 7 days. In addition, c-Myc inhibition increases CD34+ and CD133+...

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Literature Corpus work: bb67d7d9-a260-5e43-ac8e-302626cec1b7
DOI: 10.1101/403584

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