Article
Metal binding activity of the Escherichia coli hydrogenase maturation factor HypB.
Biochemistry - 13 Sept 2005
Leach Michael R, Sandal Shaifali, Sun Haowei, Zamble Deborah B
Abstract excerpt
The formation of the [NiFe] metallocenter of Escherichia coli hydrogenase 3 requires the participation of proteins encoded by the hydrogenase pleiotropy operon hypABCDEF. The insertion of Ni(II) into the precursor enzyme follows the incorporation of the iron center and is the function of HypA, a Zn(II)-binding protein, and HypB, a GTPase. The Ni(II) donor and the mechanism of transfer of Ni(II) into the...
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