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Article

Interaction between hydrogenase maturation factors HypA and HypB is required for [NiFe]-hydrogenase maturation.

PloS one - 1 Jan 2012

Chan Kwok-Ho, Lee Ka-Man, Wong Kam-Bo

Abstract excerpt

The active site of [NiFe]-hydrogenase contains nickel and iron coordinated by cysteine residues, cyanide and carbon monoxide. Metal chaperone proteins HypA and HypB are required for the nickel insertion step of [NiFe]-hydrogenase maturation. How HypA and HypB work together to deliver nickel to the catalytic core remains elusive. Here we demonstrated that HypA and HypB from Archaeoglobus fulgidus form 1:1...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22384275
DOI: 10.1371/journal.pone.0032592
PMCID: PMC3287977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Interaction between hydrogenase maturation factors HypA and HypB is required for [NiFe]-hydrogenase maturation.PMID 22384275Read ↗

Metal binding activity of the Escherichia coli hydrogenase maturation factor HypB.Semantic proximity Read ↗

Maturation of the [NiFe] hydrogenases.Semantic proximity Read ↗

Involvement of hyp gene products in maturation of the H(2)-sensing [NiFe] hydrogenase of Ralstonia eutropha.Semantic proximity Read ↗

Requirement of nickel metabolism proteins HypA and HypB for full activity of both hydrogenase and urease in Helicobacter pylori.Semantic proximity Read ↗

Dual roles of Bradyrhizobium japonicum nickelin protein in nickel storage and GTP-dependent Ni mobilization.Semantic proximity Read ↗

Nickel translocation between metallochaperones HypA and UreE in Helicobacter pyloriSemantic proximity Read ↗

Duplication of hyp genes involved in maturation of [NiFe] hydrogenases in Alcaligenes eutrophus H16.Semantic proximity Read ↗

[FeFe]- and [NiFe]-hydrogenase diversity, mechanism, and maturation.Semantic proximity Read ↗

Analysis of the transcarbamoylation-dehydration reaction catalyzed by the hydrogenase maturation proteins HypF and HypE.Semantic proximity Read ↗

The role of complex formation between the Escherichia coli hydrogenase accessory factors HypB and SlyD.Semantic proximity Read ↗

The HypB protein from Bradyrhizobium japonicum can store nickel and is required for the nickel-dependent transcriptional regulation of hydrogenase.Semantic proximity Read ↗

Nickel Ligation of the N-Terminal Amine of HypA Is Required for Urease Maturation in Helicobacter pylori.Semantic proximity Read ↗

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