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Article

Attenuation of Marek's disease virus by deletion of open reading frame RLORF4 but not RLORF5a.

Journal of virology - 1 Sept 2005

Jarosinski Keith W, Osterrieder Nikolaus, Nair Venugopal K, Schat Karel A

Abstract excerpt

Marek's disease (MD) in chickens is caused by the alphaherpesvirus MD virus (MDV) and is characterized by the development of lymphoblastoid tumors in multiple organs. The recent identification and cloning of RLORF4 and the finding that four of six attenuated strains of MDV contained deletions within RLORF4 suggested that it is involved in the attenuation process of MDV. To assess the role of RLORF4 in MD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16140742
DOI: 10.1128/JVI.79.18.11647-11659.2005
PMCID: PMC1212595

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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