Article
Mutations of epidermal growth factor receptor of non-small cell lung cancer were associated with sensitivity to gefitinib in recurrence after surgery.
Lung cancer (Amsterdam, Netherlands) - 1 Dec 2005
Kondo Masashi, Yokoyama Toshihiko, Fukui Takayuki, Yoshioka Hiromu, Yokoi Kohei, Nagasaka Tetsuro, Imaizumi Kazuyoshi, Kume Hiroaki, Hasegawa Yoshinori, Shimokata Kaoru, Sekido Yoshitaka
Abstract excerpt
The epidermal growth factor receptor (EGFR) gene has recently been reported to be mutated in a subset of non-small cell lung cancers (NSCLC), with the mutations being correlated with the patients' drug sensitivity to gefitinib, an EGFR kinase inhibitor. In this study, we searched for EGFR mutations in patients with lung cancer using primary tumor specimens obtained at initial surgery and examined whether their...
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