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Article

DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG.

Molecular cell - 2 Sept 2005

Klose Robert J, Sarraf Shireen A, Schmiedeberg Lars, McDermott Suzanne M, Stancheva Irina, Bird Adrian P

Abstract excerpt

DNA methylation is interpreted by a family of methyl-CpG binding domain (MBD) proteins that repress transcription through recruitment of corepressors that modify chromatin. To compare in vivo binding of MeCP2 and MBD2, we analyzed immunoprecipitated chromatin from primary human cells. Genomic sites occupied by the two MBD proteins were mutually exclusive. As MeCP2 was unable to colonize sites vacated by depletion...

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Source

Identifiers

PMID: 16137622
DOI: 10.1016/j.molcel.2005.07.021

Genes

MBD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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