Article
The crystal structure of human GlnRS provides basis for the development of neurological disorders.
Nucleic acids research - 20 Apr 2016
Ognjenović Jana, Wu Jiang, Matthies Doreen, Baxa Ulrich, Subramaniam Sriram, Ling Jiqiang, Simonović Miljan
Abstract excerpt
Cytosolic glutaminyl-tRNA synthetase (GlnRS) is the singular enzyme responsible for translation of glutamine codons. Compound heterozygous mutations in GlnRS cause severe brain disorders by a poorly understood mechanism. Herein, we present crystal structures of the wild type and two pathological mutants of human GlnRS, which reveal, for the first time, the domain organization of the intact enzyme and the...
Topics
- Amino Acyl-tRNA Synthetases
- Crystallography, X-Ray
- Humans
- Models, Molecular
- Mutation
- Nervous System Diseases
- Protein Folding
- Protein Structure, Tertiary