Article
Patterns of beta-catenin expression in gastric carcinoma: clinicopathological relevance and mutation analysis.
International journal of surgical pathology - 1 Jan 2003
Nabais Sérgio, Machado José Carlos, Lopes Carlos, Seruca Raquel, Carneiro Fátima, Sobrinho-Simões Manuel
Abstract excerpt
Studies on the expression of beta-catenin (beta-ct) in gastric carcinoma have provided conflicting results, and the role played by beta-ct mutations in gastric carcinogenesis remains unclear. In an attempt to clarify the aforementioned issues we undertook the retrospective study of 157 gastric carcinomas by using immunohistochemistry and molecular genetics. Reduced/absent membranous beta-ct expression was...
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