Article
Analysis of the Foxp3/scurfin gene in Crohn's disease.
Annals of the New York Academy of Sciences - 1 Jun 2005
Park Ogyi, Grishina Irina, Leung Patrick S, Gershwin M Eric, Prindiville T
Abstract excerpt
Crohn's disease (CD) is a chronic inflammatory bowel disease typified by transmural inflammation affecting any part of the gastrointestinal tract. CD4(+)CD25(+) regulatory T cells (T(reg) cells) play important roles in intestinal homeostasis. Adoptive transfer of regulatory T cells into mice with chronic colitis prevented inflammation and reappearance of normal intestinal architecture. The Foxp3 gene encodes a...
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