Strand-separating conformational polymorphism analysis: efficacy of detection of point mutations in the human ornithine delta-aminotransferase gene.

doi:10.1016/0888-7543(92)90258-t

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Article

Strand-separating conformational polymorphism analysis: efficacy of detection of point mutations in the human ornithine delta-aminotransferase gene.

Genomics - 1 Jun 1992

Michaud J, Brody L C, Steel G, Fontaine G, Martin L S, Valle D, Mitchell G

Abstract excerpt

We tested the use of a modified method of single-strand conformational polymorphism (SSCP) analysis for the detection of point mutations in the human ornithine-delta-aminotransferase gene. Using a combination of three different electrophoretic conditions, we detected 20/20 known mutations. In a p...

Topics

Base Sequence
DNA Mutational Analysis
DNA, Single-Stranded
Electrophoresis, Polyacrylamide Gel
Exons
Genes
Humans
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Nucleic Acid Denaturation
Ornithine-Oxo-Acid Transaminase
Polymerase Chain Reaction
Polymorphism, Genetic

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PMID: 1612597
DOI: 10.1016/0888-7543(92)90258-t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1612597-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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