Article
Blood oxidative stress markers in Gaucher disease patients.
Clinica chimica acta; international journal of clinical chemistry - 1 Feb 2006
Roversi Fernanda M, Galdieri Luciano C, Grego Bruno H C, Souza Fernanda G, Micheletti Cecília, Martins Ana Maria, D'Almeida Vânia
Abstract excerpt
BACKGROUND: Gaucher disease (GD) is the most common glycosphingolipidosis resulting in accumulation of glucoceramide. The most effective treatment for this disease is enzyme replacement therapy (ERT) which involves recombinant enzyme infusion. Enzymatic deficiency in GD patients may induce a cascade of events culminating in secondary effects such as the production of reactive oxygen species (ROS). We investigated...
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