Article
Neuropsychological function in nondemented carriers of presenilin-1 mutations.
Neurology - 23 Aug 2005
Ringman J M, Diaz-Olavarrieta C, Rodriguez Y, Chavez M, Fairbanks L, Paz F, Varpetian A, Maldonado H C, Macias-Islas M A, Murrell J, Ghetti B, Kawas C
Abstract excerpt
BACKGROUND: Prospective and case-control studies have demonstrated that memory loss and executive dysfunction occur early in Alzheimer disease (AD). OBJECTIVE: To investigate these observations by the study of persons at risk for autosomal dominant forms of AD. METHODS: Neuropsychological and genetic tests were performed on 51 nondemented at-risk members of 10 Mexican families with two distinct presenilin-1 (PS1)...
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