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Article

Age-dependent cognitive changes in carriers of the fragile X syndrome.

Cortex; a journal devoted to the study of the nervous system and behavior - 1 Jun 2008

Cornish Kim M, Li Lexin, Kogan Cary S, Jacquemont Sebastien, Turk Jeremy, Dalton Ann, Hagerman Randi J, Hagerman Paul J

Abstract excerpt

Fragile X syndrome is a neurodevelopmental disorder that is caused by the silencing of a single gene on the X chromosome, the fragile X mental retardation 1 (FMR1) gene. Affected individuals display a unique neurocognitive phenotype that includes significant impairment in inhibitory control, selective attention, working memory, and visual-spatial cognition. In contrast, little is known about the trajectory and...

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Source

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Identifiers

PMID: 18472033
DOI: 10.1016/j.cortex.2006.11.002
PMCID: PMC11060834

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age-dependent cognitive changes in carriers of the fragile X syndrome.PMID 18472033Read ↗

Mapping self-reports of working memory deficits to executive dysfunction in Fragile X Mental Retardation 1 (FMR1) gene premutation carriers asymptomatic for FXTAS.Semantic proximity Read ↗

Neuropsychological findings from older premutation carrier males and their noncarrier siblings from families with fragile X syndrome.Semantic proximity Read ↗

The emerging fragile X premutation phenotype: evidence from the domain of social cognition.Semantic proximity Read ↗

Capturing the fragile X premutation phenotypes: a collaborative effort across multiple cohorts.Semantic proximity Read ↗

Selective executive markers of at-risk profiles associated with the fragile X premutation.Semantic proximity Read ↗

Differential impact of the FMR-1 full mutation on memory and attention functioning : a neuropsychological perspective.Semantic proximity Read ↗

Relationships between motor scores and cognitive functioning in FMR1 female premutation X carriers indicate early involvement of cerebello-cerebral pathways.Semantic proximity Read ↗

An fMRI study of the prefrontal activity during the performance of a working memory task in premutation carriers of the fragile X mental retardation 1 gene with and without fragile X-associated tremor/ataxia syndrome (FXTAS).Semantic proximity Read ↗

Selective spatial processing deficits in an at-risk subgroup of the fragile X premutation.Semantic proximity Read ↗

Relationships between motor scores and cognitive functioning in FMR1 female premutation X carriers indicate early involvement of cerebello-cerebral pathwaysSemantic proximity Read ↗

Investigation of memory, executive functions, and anatomic correlates in asymptomatic FMR1 premutation carriers.Semantic proximity Read ↗

Young adult female fragile X premutation carriers show age- and genetically-modulated cognitive impairments.Semantic proximity Read ↗

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