Article
Dementia and neurodevelopmental predisposition: cognitive dysfunction in presymptomatic subjects precedes dementia by decades in frontotemporal dementia.
Annals of neurology - 1 Dec 2001
Geschwind D H, Robidoux J, Alarcón M, Miller B L, Wilhelmsen K C, Cummings J L, Nasreddine Z S
Abstract excerpt
Dementia is typically thought of as a disease caused by the process of aging. Few studies have addressed the premorbid neuropsychological alterations in subjects at risk for the disease--an issue of great importance for the understanding and treatment of degenerative dementias. We used knowledge of the mutation carrier status in a family with inherited dementia to address this issue more efficiently than is...
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