Article
A variant serum cholinesterase and a confirmed point mutation at Gly-365 to Arg found in a patient with liver cirrhosis.
Internal medicine (Tokyo, Japan) - 1 Mar 1992
Hada T, Muratani K, Ohue T, Imanishi H, Moriwaki Y, Itoh M, Amuro Y, Higashino K
Abstract excerpt
A 64-year-old man was admitted to our hospital because of possible liver cirrhosis. His serum cholinesterase was anomalously low with a delta pH of 0.1 (normal range; 0.8-1.1). His enzyme was more heat-labile than the normal controls. Km value of his enzyme for benzoylcholine was 1.1 x 10(-5) mol...
Topics
- Amino Acid Sequence
- Base Sequence
- Cholinesterases
- DNA
- Genetic Variation
- Humans
- Immunochemistry
- Isoenzymes
- Kinetics
- Liver Cirrhosis
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polydeoxyribonucleotides
- Polymerase Chain Reaction