A PCR based method to determine the Kalow allele of the cholinesterase gene: the E1k allele frequency and its significance in the normal population.

doi:10.1136/jmg.31.3.248

Back to search

Article

A PCR based method to determine the Kalow allele of the cholinesterase gene: the E1k allele frequency and its significance in the normal population.

Journal of medical genetics - 1 Mar 1994

Gaffney D, Campbell R A

Abstract excerpt

The Kalow allele for cholinesterase is a quantitative variant of the usual gene and has been shown to result from a single base pair change in the DNA. A new method based on the polymerase chain reaction to distinguish Kalow alleles of the cholinesterase gene was developed. Using the amplificatio...

Topics

Adult
Alleles
Base Sequence
Cholinesterases
DNA Mutational Analysis
Female
Gene Frequency
Genes
Genotype
Humans
Male
Middle Aged
Molecular Sequence Data
Point Mutation
Polymerase Chain Reaction

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.