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Article

Naturally occurring mutation Leu307Pro of human butyrylcholinesterase in the Vysya community of India.

Pharmacogenetics and genomics - 1 Jul 2006

Manoharan Indumathi, Wieseler Stacy, Layer Paul G, Lockridge Oksana, Boopathy Rathnam

Abstract excerpt

BACKGROUND: People with genetic variants of butyrylcholinesterase (EC 3.1.1.8, BChE) can have hours of prolonged apnea after a normal dose of succinylcholine or mivacurium. METHODS: Plasma samples from 226 people in the Vysya community in Coimbatore, India were tested for BChE activity. RESULTS: Nine unrelated individuals had no detectable activity. DNA sequencing revealed a novel mutation in exon 2 of the BCHE...

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Source

Identifiers

PMID: 16788378
DOI: 10.1097/01.fpc.0000197464.37211.77

Genes

BCHE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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