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Article

Interferon reduces somatic mutation of mitochondrial DNA in liver tissues from chronic viral hepatitis patients.

Journal of viral hepatitis - 1 Sept 2005

Nishikawa M, Nishiguchi S, Kioka K, Tamori A, Inoue M

Abstract excerpt

SUMMARY: We recently reported that the genetic instability resulting in the high rate of mitochondrial DNA (mtDNA) mutation in noncancerous liver tissue is consistent with the multicentric hepatocarcinogenesis detected clinically. Interferon (IFN) has been reported to reduce hepatocarcinogenesis in individuals with hepatitis virus infection. Liver biopsy specimens were obtained from 26 patients with chronic...

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Share to Antiviral Agents
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Mitochondrial

Share to Hepatitis B, Chronic

Share to Hepatitis C, Chronic

Share to Interferons

Share to Liver Neoplasms

Share to RNA, Viral

Source

Identifiers

PMID: 16108764
DOI: 10.1111/j.1365-2893.2005.00623.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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