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Article

Neural stem cell transplantation can ameliorate the phenotype of a mouse model of spinal muscular atrophy.

The Journal of clinical investigation - 1 Oct 2008

Corti Stefania, Nizzardo Monica, Nardini Martina, Donadoni Chiara, Salani Sabrina, Ronchi Dario, Saladino Francesca, Bordoni Andreina, Fortunato Francesco, Del Bo Roberto, Papadimitriou Dimitra, Locatelli Federica, Menozzi Giorgia, Strazzer Sandra, Bresolin Nereo, Comi Giacomo P

Abstract excerpt

Spinal muscular atrophy (SMA), a motor neuron disease (MND) and one of the most common genetic causes of infant mortality, currently has no cure. Patients with SMA exhibit muscle weakness and hypotonia. Stem cell transplantation is a potential therapeutic strategy for SMA and other MNDs. In this study, we isolated spinal cord neural stem cells (NSCs) from mice expressing green fluorescent protein only in motor...

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Identifiers

PMID: 18769634
DOI: 10.1172/JCI35432
PMCID: PMC2525699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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