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Article

Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice.

Neurobiology of aging - 1 Apr 2014

Turner Bradley J, Alfazema Neza, Sheean Rebecca K, Sleigh James N, Davies Kay E, Horne Malcolm K, Talbot Kevin

Abstract excerpt

Spinal muscular atrophy results from diminished levels of survival motor neuron (SMN) protein in spinal motor neurons. Low levels of SMN also occur in models of amyotrophic lateral sclerosis (ALS) caused by mutant superoxide dismutase 1 (SOD1) and genetic reduction of SMN levels exacerbates the phenotype of transgenic SOD1(G93A) mice. Here, we demonstrate that SMN protein is significantly reduced in the spinal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24210254
DOI: 10.1016/j.neurobiolaging.2013.09.030
PMCID: PMC3919158

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice.PMID 24210254Read ↗

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