Article
Serum from achalasia patients alters neurochemical coding in the myenteric plexus and nitric oxide mediated motor response in normal human fundus.
Gut - 1 Mar 2006
Bruley des Varannes S, Chevalier J, Pimont S, Le Neel J-C, Klotz M, Schafer K-H, Galmiche J-P, Neunlist M
Abstract excerpt
BACKGROUND AND AIMS: Achalasia is a disease of unknown aetiology. An immune mechanism has been suggested on the basis of previous morphological observations. The objective of this study was to test whether the serum of achalasia patients could reproduce the phenotype and functional changes that occur with disease progression in an ex vivo human model. METHODS: Specimens of normal human fundus were maintained in...
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