Article
Intercellular gamma-herpesvirus dissemination involves co-ordinated intracellular membrane protein transport.
Traffic (Copenhagen, Denmark) - 1 Sept 2005
May Janet S, de Lima Brigitte D, Colaco Susanna, Stevenson Philip G
Abstract excerpt
The murine gamma-herpesvirus-68 (MHV-68) ORF27 encodes gp48, a type 2 transmembrane glycoprotein that contributes to intercellular viral spread. Gp48 is expressed on the surface of infected cells but is retained intracellularly after transfection. In this study, we show that the multimembrane spanning ORF58 gene product is both necessary and sufficient for gp48 to reach the cell surface. ORF58-deficient MHV-68...
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