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Article

Deuterium and its role in the machinery of evolution.

Journal of theoretical biology - 21 Feb 2006

Pedersen Lee G, Bartolotti Lee, Li Leping

Abstract excerpt

An argument is presented that the spontaneous mutation rate, the core of evolution theory, may be dictated by the deuterium/hydrogen (D/H) abundance ratio. This argument is supported by quantum mechanical calculations of the zero-point energy reduction for DNA base pairs upon deuterium substitution for hydrogen and recent experiments that show that the rate of catalytic dsDNA unwinding is dependent on the...

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PMID: 16098990
DOI: 10.1016/j.jtbi.2005.07.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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