Article
Association of dopamine beta-hydroxylase polymorphism with hypertension through interaction with fasting plasma glucose in Japanese.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Mar 2005
Abe Michiko, Wu Zhihong, Yamamoto Miyuki, Jin Jing Ji, Tabara Yasuharu, Mogi Masaki, Kohara Katsuhiko, Miki Tetsuro, Nakura Jun
Abstract excerpt
Dopamine-beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine and is released from sympathetic neurons into the circulation. Several lines of evidence, including the finding of elevated plasma DBH activity in essential hypertension, suggest an important role of DBH in hypertension. Recently, a novel polymorphism (-1021C/T) in the 5' flanking region of the DBH gene has been shown to...
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