Article
No evidence for an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder.
Psychiatric genetics - 1 Sept 2005
Abou Jamra Rami, Schumacher Johannes, Becker Tim, Dahdouh Faten, Ohlraun Stephanie, Suliman Husam, Schulze Thomas G, Tullius Monja, Kovalenko Svetlana, Maier Wolfgang, Rietschel Marcella, Propping Peter, Nöthen Markus M, Cichon Sven
Abstract excerpt
The proline dehydrogenase locus must be considered as a positional and functional candidate in schizophrenia. It is located in the chromosomal region of the velocardiofacial syndrome on 22q11 that is suspected to contain genes relevant to schizophrenia, and is involved in the metabolism of neurotransmitters. Positive association between single-nucleotide polymorphisms at the proline dehydrogenase locus and...
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