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Article

Spontaneous thermal motion of the GABA(A) receptor M2 channel-lining segments.

The Journal of biological chemistry - 21 Oct 2005

Bera Amal K, Akabas Myles H

Abstract excerpt

The gamma-aminobutyric acid type A (GABA(A)) receptor channel opening involves translational and rotational motions of the five channel-lining, M2 transmembrane segments. The M2 segment's extracellular half is loosely packed and undergoes significant thermal motion. To characterize the extent of the M2 segment's motion, we used disulfide trapping experiments between pairs of engineered cysteines. In alpha1beta1...

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Identifiers

PMID: 16091360
DOI: 10.1074/jbc.M504645200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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