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Article

Loose protein packing around the extracellular half of the GABA(A) receptor beta1 subunit M2 channel-lining segment.

The Journal of biological chemistry - 19 Mar 2004

Goren Eric N, Reeves David C, Akabas Myles H

Abstract excerpt

GABA(A) receptors are ligand-gated ion channels formed by the pseudosymmetrical assembly of five homologous subunits around the central channel axis. The five M2 membrane-spanning segments largely line the channel. In the present work we probed the water surface accessibility of the beta(1) subunit M2 segment using the substituted cysteine accessibility method. We assayed the reaction of the negatively charged...

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Identifiers

PMID: 14715650
DOI: 10.1074/jbc.M314050200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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