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Mast cells and complement system: Ancient interactions between components of innate immunity

23 May 2020

Abstract excerpt

The emergence and evolution of the complement system and mast cells (MCs) can be traced back to sea urchins and the ascidian Styela plicata, respectively. Acting as a cascade of enzymatic reactions, complement is activated through the classical (CP), the alternative (AP), and the lectin pathway (LP) based on the recognized molecules. The system's main biological functions include lysis, opsonization, and...

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PMID: 32446274
DOI: 10.1111/all.14413

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