Article
CD133-positive hematopoietic stem cell "stemness" genes contain many genes mutated or abnormally expressed in leukemia.
Stem cells (Dayton, Ohio) - 1 Sept 2005
Toren Amos, Bielorai Bella, Jacob-Hirsch Jasmine, Fisher Tamar, Kreiser Doron, Moran Orit, Zeligson Sharon, Givol David, Yitzhaky Assif, Itskovitz-Eldor Joseph, Kventsel Iris, Rosenthal Esther, Amariglio Ninette, Rechavi Gideon
Abstract excerpt
Affymetrix human Hu133A oligonucleotide arrays were used to study the expression profile of CD133+ cord blood (CB) and peripheral blood (PB) using CD133 cell-surface marker. An unsupervised hierarchical clustering of 14,025 valid probe sets showed a clear distinction between the CD133+ cells representing the hematopoietic stem cell (HSC) population and CD133-differentiated cells. Two hundred forty-four genes were...
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