Article
Interleukin-1 gene cluster polymorphisms are associated with nutritional status and inflammation in patients with end-stage renal disease.
Blood purification - 1 Jan 2005
Maruyama Yukio, Nordfors Louise, Stenvinkel Peter, Heimburger Olof, Bárány Peter, Pecoits-Filho Roberto, Axelsson Jonas, Hoff Catherine M, Holmes Clifford J, Schalling Martin, Lindholm Bengt
Abstract excerpt
BACKGROUND: Wasting and inflammation are two common risk factors for death in patients with end-stage renal disease (ESRD). Interleukin-1beta (IL-1beta) and its receptor antagonist (IL-1Ra) may play a pivotal role in the pathogenesis of wasting and inflammation. METHODS: To investigate effects of the IL-1 gene cluster polymorphisms on wasting and inflammation, we studied 189 ESRD patients (52+/- 12 years, 62%...
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