Article
Microsatellite instability is linked to loss of hMLH1 expression in advanced gastric cancers: lack of a relationship with the histological type and phenotype.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Jan 2005
Mizoshita Tsutomu, Tsukamoto Tetsuya, Cao Xueyuan, Otsuka Takafumi, Ito Seiji, Takahashi Emiko, Nakamura Shigeo, Nakamura Tsuneya, Yamamura Yoshitaka, Tatematsu Masae
Abstract excerpt
BACKGROUND: It has been suggested that the prevalence of microsatellite instability (MSI) is high in intramucosal differentiated gastric cancers with gastric foveolar phenotypic expression, and that these tumors are prone to lose their glandular structures and progress to undifferentiated-type lesions. To test this hypothesis, we examined the relationships among human MutL homologue 1 (hMLH1) expression (which is...
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