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Article

Chemical genetic engineering of G protein-coupled receptor kinase 2.

The Journal of biological chemistry - 14 Oct 2005

Kenski Denise M, Zhang Chao, von Zastrow Mark, Shokat Kevan M

Abstract excerpt

G protein-coupled receptor kinases (GRKs) play a pivotal role in receptor regulation. Efforts to study the acute effects of GRKs in intact cells have been limited by a lack of specific inhibitors. In the present study we have developed an engineered version of GRK2 that is specifically and reversibly inhibited by the substituted nucleotide analog 1-naphthyl-PP1 (1Na-PP1), and we explored GRK2 function in...

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Source

Identifiers

PMID: 16081410
DOI: 10.1074/jbc.M507594200

Genes

GRK2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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