Article
HBx M130K and V131I (T-A) mutations in HBV genotype F during a follow-up study in chronic carriers
4 Aug 2005
Abstract excerpt
BACKGROUND: Around 400 million people worldwide are chronically infected with Hepatitis B virus (HBV). An estimated 10% of these chronic patients develop progressive liver damage including cirrhosis and Hepatocellular Carcinoma (HCC). The HBx gene encodes a protein of 154 amino acids which is a transactivator and has been associated with HBV pathogenesis. A change in the amino acid sequences at positions 130 and...
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