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Article

Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor

1 Aug 2005

Abstract excerpt

Overexpression of the transcription factor Snail in epithelial MDCK cells promotes the epithelial-mesenchymal transition (EMT) and the acquisition of an invasive phenotype. We report here that the expression of Snail is associated with an increase in the promoter activity and expression of the matrix metalloproteinase MMP-9. The effect of Snail silencing on MMP-9 expression corroborates this finding. Induced...

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PMID: 16079281
DOI: 10.1242/jcs.02465

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