Article
The Ama1-directed anaphase-promoting complex regulates the Smk1 mitogen-activated protein kinase during meiosis in yeast.
Genetics - 1 Nov 2005
McDonald Christine M, Cooper Katrina F, Winter Edward
Abstract excerpt
Smk1 is a meiosis-specific MAPK homolog in Saccharomyces cerevisiae that regulates the postmeiotic program of spore formation. Similar to other MAPKs, it is activated via phosphorylation of the T-X-Y motif in its regulatory loop, but the signals controlling Smk1 activation have not been defined. Here we show that Ama1, a meiosis-specific activator of the anaphase-promoting complex/cyclosome (APC/C), promotes Smk1...
Topics
- Anaphase-Promoting Complex-Cyclosome
- CDC28 Protein Kinase, S cerevisiae
- Cdc20 Proteins
- Cell Cycle Proteins
- Gene Expression Regulation, Fungal
- Meiosis
- Mitogen-Activated Protein Kinases
- Mutation
- Protein Tyrosine Phosphatases
- Saccharomyces cerevisiae