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Article

Laccase 2 is the phenoloxidase gene required for beetle cuticle tanning.

Proceedings of the National Academy of Sciences of the United States of America - 9 Aug 2005

Arakane Yasuyuki, Muthukrishnan Subbaratnam, Beeman Richard W, Kanost Michael R, Kramer Karl J

Abstract excerpt

Cuticle tanning (or sclerotization and pigmentation) in invertebrates involves the oxidative conjugation of proteins, which renders them insoluble and hardens and darkens the color of the exoskeleton. Two kinds of phenoloxidases, laccase and tyrosinase, have been proposed to participate in tanning, but proof of the true identity of the enzyme(s) responsible for this process has been elusive. We report the cloning...

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Identifiers

PMID: 16076951
DOI: 10.1073/pnas.0504982102
PMCID: PMC1183588

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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