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Article

Mechanisms of disease: the impact of antithrombotic therapy in cancer patients.

Nature clinical practice. Oncology - 1 Jul 2005

Petralia Gloria A, Lemoine Nick R, Kakkar Ajay K

Abstract excerpt

Venous thromboembolism is a common complication in patients with malignant disease. It is associated with a systemic hypercoagulable state that is secondary to tumor elaboration of tissue factor (the physiological initiator of blood coagulation), activation of other procoagulant mechanisms and downregulation of anticoagulant mechanisms. The consequent generation of activated coagulation serine protease in the...

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PMID: 16075795
DOI: 10.1038/ncponc0225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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