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Article

Transmission of the fra(X) haplotype from three nonpenetrant brothers to their affected grandsons.

American journal of medical genetics - 1 Jun 1992

Kirkilionis A J, Chudley A E, Greenberg C R, Yan D L, McGillivray B, Hamerton J L

Abstract excerpt

We report on a family showing transmission of the fra(X) gene by 3 nonpenetrant, fra(X) negative, normally intelligent, full and half-brothers to their affected grandsons. The mothers of the affected boys are obligate carriers, fra(X) negative, and of normal intelligence. This family illustrates the "Sherman Paradox" and is compatible with the predictions of the Laird X-inactivation imprinting model. In addition,...

Topics

Chromosome Mapping
DNA
Fragile X Syndrome
Genetic Linkage
Haplotypes
Humans
Male
Pedigree
Phenotype

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1605253
DOI: 10.1002/ajmg.1320430316

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1605253-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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