Article
Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2005
Song Jiannan, da Costa Kerry Ann, Fischer Leslie M, Kohlmeier Martin, Kwock Lester, Wang Shuli, Zeisel Steven H
Abstract excerpt
Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes phosphatidylcholine synthesis. PEMT knockout mice have fatty livers, and it is possible that, in humans, nonalcoholic fatty liver disease (NAFLD) might be associated with PEMT gene polymorphisms. DNA samples from 59 humans without fatty liver and from 28 humans with NAFLD were genotyped for a single nucleotide polymorphism in exon 8 of PEMT, which...
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