Article
The phosphatidylethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population.
Journal of hepatology - 1 May 2007
Dong Hang, Wang Jianjie, Li Chunmei, Hirose Akira, Nozaki Yasuko, Takahashi Masaya, Ono Masafumi, Akisawa Naoaki, Iwasaki Shinji, Saibara Toshiji, Onishi Saburo
Abstract excerpt
BACKGROUND/AIMS: The genetic predisposition on the development of nonalcoholic steatohepatitis (NASH) has been poorly understood. A functional polymorphism Val175Met was reported in phosphatidylethanolamine N-methyltransferase (PEMT) that catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine. The aim of this study was to investigate whether the carriers of Val175Met variant impaired in PEMT...
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