Comparative analyses of the Conserved Oligomeric Golgi (COG) complex in vertebrates

doi:10.1186/1471-2148-10-212

Article

Comparative analyses of the Conserved Oligomeric Golgi (COG) complex in vertebrates

1 Jan 2010

Abstract excerpt

BACKGROUND: The Conserved Oligomeric Golgi (COG) complex is an eight-subunit assembly that localizes peripherally to Golgi membranes and is involved in retrograde vesicular trafficking. COG subunits are organized in two heterotrimeric groups, Cog2, -3, -4 and Cog5, -6, -7, linked by a dimeric group formed by Cog1 and Cog8. Dysfunction of COG complex in humans has been associated with new forms of Congenital...

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