Article
Perspective: Sign epistasis and genetic constraint on evolutionary trajectories.
Evolution; international journal of organic evolution - 1 Jun 2005
Weinreich Daniel M, Watson Richard A, Chao Lin
Abstract excerpt
Epistasis for fitness means that the selective effect of a mutation is conditional on the genetic background in which it appears. Although epistasis is widely observed in nature, our understanding of its consequences for evolution by natural selection remains incomplete. In particular, much attention focuses only on its influence on the instantaneous rate of changes in frequency of selected alleles via epistatic...
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