Article
Selection biases the prevalence and type of epistasis along adaptive trajectories.
Evolution; international journal of organic evolution - 1 Nov 2013
Draghi Jeremy A, Plotkin Joshua B
Abstract excerpt
The contribution to an organism's phenotype from one genetic locus may depend upon the status of other loci. Such epistatic interactions among loci are now recognized as fundamental to shaping the process of adaptation in evolving populations. Although little is known about the structure of epistasis in most organisms, recent experiments with bacterial populations have concluded that antagonistic interactions...
Topics
- Adaptation, Biological
- Biological Evolution
- Epistasis, Genetic
- Escherichia coli
- Evolution, Molecular
- Genetic Fitness
- Models, Genetic
- Mutation
- Selection, Genetic