Article
Effects of HIV-1 infection on lymphocyte phenotypes in blood versus lymph nodes.
Journal of acquired immune deficiency syndromes (1999) - 15 Aug 2005
Yang Otto O, Ferbas John J, Hausner Mary Ann, Hultin Lance E, Hultin Patricia M, McFadden David, Sawicki Mark, Detels Roger, Majchrowicz Martin, Matud Jose L, Giorgi Janis V, Jamieson Beth D
Abstract excerpt
Most immunopathogenesis studies of HIV-1 use peripheral blood. Most lymphocytes reside in lymphoid tissues, however, and the extent to which blood mirrors tissues is unclear. Here, we analyze lymphocytes in blood and lymph nodes of HIV-1-uninfected and -infected persons. Baseline comparison of node and blood lymphocytes in seronegative persons demonstrates a lower ratio of CD8+ versus CD4+ T lymphocytes, a lower...
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