Article
No increased susceptibility to breast cancer from combined CHEK2 1100delC genotype and the HLA class III region risk factors.
European journal of cancer (Oxford, England : 1990) - 1 Aug 2005
de Jong Mirjam M, Nolte Ilja M, Te Meerman Gerard J, van der Graaf Winette T A, Oosterom Elvira, Bruinenberg Marcel, Steege Gerrit van der, Oosterwijk Jan C, van der Hout Annemarie H, Boezen H Marike, Schaapveld Michael, Kleibeuker Jan H, de Vries Elisabeth G E
Abstract excerpt
CHEK2 is low-penetrance breast cancer susceptibility gene. The 1100delC mutation may interact with variants/mutations in other breast cancer susceptibility loci. We identified a risk haplotype in the HLA class III region in breast cancer patients [de Jong MM, Nolte IM, de Vries EGE, et al. The HLA class III subregion is responsible for an increased breast cancer risk. Hum Mol Genet 2003, 12, 2311-2319] and tested...
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