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Article

The Role of Chemokines in Mediating Graft Versus Host Disease: Opportunities for Novel Therapeutics

1 Jan 2012

Abstract excerpt

Bone marrow transplantation (BMT) is the current therapy of choice for several malignancies and severe autoimmune diseases. Graft versus host disease (GVHD) is the major complication associated with BMT. T lymphocytes and other leukocytes migrate into target organs during GVHD, become activated and mediate tissue damage. Chemokines are well known inducers of leukocyte trafficking and activation and contribute to...

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PMID: 22375119
DOI: 10.3389/fphar.2012.00023

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