Article
The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice
15 Jul 2005
Abstract excerpt
The molecular characterization of leukemia has demonstrated that genetic alterations in the leukemic clone frequently fall into 2 classes, those affecting transcription factors (e.g., AML1-ETO) and mutations affecting genes involved in signal transduction (e.g., activating mutations of FLT3 and KIT). This finding has favored a model of leukemogenesis in which the collaboration of these 2 classes of genetic...
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