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Article

Interaction between CYP19 aromatase and butyrylcholinesterase genes increases Alzheimer's disease risk.

Dementia and geriatric cognitive disorders - 1 Jan 2005

Combarros Onofre, Riancho José A, Infante Jon, Sañudo Carolina, Llorca Javier, Zarrabeitia María T, Berciano José

Abstract excerpt

Biological evidence supports a role of aromatase and butyrilcholinesterase (BCHE) enzymes in the disruption of the cholinergic neurotransmission observed in Alzheimer's disease (AD). Estrogens may reduce the risk of AD through enhancing or preserving cholinergic neurotransmission, and aromatase, the product of the CYP19 gene, is a critical enzyme in the peripheral synthesis of estrogens. BCHE is a hydrolytic...

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Source

Identifiers

PMID: 16020944
DOI: 10.1159/000087065

Genes

BCHE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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